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課程名稱 |
系統回顧與統合分析
Systematic Review and Meta-analysis |
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開課學期 |
99-2 |
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授課對象 |
公共衛生學院 流預所流行病學組 |
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授課教師 |
林先和 |
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課號 |
EPM5053 |
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課程識別碼 |
849 U0240 |
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班次 |
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學分 |
2 |
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全/半年 |
半年 |
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必/選修 |
選修 |
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上課時間 |
星期四7,8(14:20~16:20) |
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上課地點 |
公衛211 |
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備註 |
總人數上限：50人 |
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Ceiba 課程網頁 |
http://ceiba.ntu.edu.tw/992meta |
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課程簡介影片 |
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核心能力關聯 |
本課程尚未建立核心能力關連 |
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課程大綱
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為確保您我的權利,請尊重智慧財產權及不得非法影印
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課程概述 |
This course will introduce students to the principles in conducting a systematic and quantitative review of randomised controlled trials and observational studies. The course will be structured by the critical steps in conducting a systematic review and meta-analysis, with particular emphasis on common pitfalls when doing such an analysis. A series of case studies of important public health and medical issues will be used as in-class examples. The course consists of lectures, computer labs using common software packages for meta-analysis, and a final group project resulting in a draft meta-analysis paper. |
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課程目標 |
The goal of the course is to provide the students the general framework of conducting a systematic review and meta-analysis. At the end of the course the students are expected to be able to read and critically appraise the literature of systematic review and meta-analysis and to conduct his or her own meta-analysis. |
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課程要求 |
The students are expected to have taken introductory-level courses of epidemiology and biostatistics. The final group project (with a group size of 2~4) will be a meta-analysis report that can be submitted for publication after further revision. |
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預期每週課後學習時數 |
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Office Hours |
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指定閱讀 |
The readings of each lecture will be posted on the course schedule and uploaded to CEIBA. |
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參考書目 |
1. Introduction to Meta-Analysis (Statistics in Practice), Michael Borenstein,
Larry Hedges, Julian Higgins, and Hannah Rothstein. Wiley, 2009.
2. Systematic Reviews in Health Care: Meta-analysis in Context, 2nd Edition,
Matthias Egger, George Davey Smith, and Douglas Altman, eds. BMJ Books, 2001.
(available as an eBook at NTU Library)
3. Cochrane Handbook for Systematic Reviews of Interventions, Julian Higgins,
Sally Green, eds. Wiley-Blackwell, 2008. (available online at
http://www.cochrane-handbook.org/) |
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評量方式
(僅供參考) |
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No. |
項目 |
百分比 |
說明 |
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1. |
class participation |
20% |
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2. |
critique |
10% |
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3. |
presentation |
10% |
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4. |
final group project |
60% |
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週次 |
日期 |
單元主題 |
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第1週 |
2/24 |
Introduction and course overview |
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第2週 |
3/03 |
Literature review and searching methods - Dr. Chia-Hsuin Chang |
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第3週 |
3/10 |
Issues of study design and analysis in clinical trials and observational studies |
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第4週 |
3/17 |
1. Study critique
2. Selecting studies and extracting data
[Submit the study critique homework] |
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第5週 |
3/24 |
Assessing the quality of included studies
[Submit the list of groups for the final project] |
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第6週 |
3/31 |
1. Fixed-effect and random-effects models
2. Assessing heterogeneity |
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第7週 |
4/07 |
Lab I (Stata) |
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第8週 |
4/14 |
Student presentation: research topic, search protocol, and preliminary search results |
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第9週 |
4/21 |
Subgroup analysis;
Meta-regression |
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第10週 |
4/28 |
Publication bias and other reporting biases
- Dr. Chia-Hsuin Chang |
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第11週 |
5/05 |
Lab II (Stata)
(if time allows: other statistical software for meta-analysis: RevMan, R) |
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第12週 |
5/12 |
Network meta-analysis - Professor Yu-Kang Tu |
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第13週 |
5/19 |
Meta-analysis of evaluations of diagnostic and screening tests - Dr. Chien-Chang Lee |
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第14週 |
5/26 |
Publication bias and other reporting biases |
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第15週 |
6/02 |
Interpreting the results and reporting systematic review and meta-analysis |
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第16週 |
6/09 |
Using systematic reviews in practice |
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第17週 |
6/16 |
Group project presentation + concluding remarks [*Final report due*] |
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